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GRX-mediated oxidation by GSSG starts with the glutathionylation of the reactive cysteine of GRX (GRX-SG)

The injections are generally conducted under local anesthesia, and multiple injections may be administered over a period of time for maximum effectiveness

Dihexa's oral activity is attributed to its small size, modified N-terminus (hexanoic acid cap), and hydrophobic character

Lang T, Croal B

The compound is supplied as a lyophilized powder because peptides in liquid form degrade rapidly the freeze-dried format keeps the compound stable at room temperature for 1218 months when protected from light and moisture