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Central regulators of mitochondrial reprogramming: coordinated control by metabolic enzymes, spatiotemporal heterogeneity, and post-transcriptional networks Building on previous sections that examined how CRC develops resistance through mitochondrial metabolic reprogramming, this section explores three key regulatory mechanisms that sustain such adaptability

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They provide oxygen and nutrients to infiltrating immune cells and activated fibroblasts, thereby directly supporting tophus growth (168)