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Based on impressive results from numerous phase-3 trials, semaglutide has gained clearance from the United States Food and Drug Administration (FDA) for several indications, including: In 2017, semaglutide was initially approved as an adjunct to diet and exercise in adult type 2 diabetics

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Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice