Mar 20, 2026 Tirzepatide and retatrutide look nearly identical on paper
The swelling on my neck visibly reduced, and as time went on, the results only got better
Nauck MA et al (2011): Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
Its once-daily dosing, compared to Ozempic and Wegovys once-weekly dosing, provides flexibility in titration for prescribers and increased adherence for patients who may not be able to keep track of what day of the week they inject
According to Truveta Research presented at ISPOR 2025, side effects were the leading reason patients stopped taking GLP-1 medications, accounting for 28.2% of all discontinuations
For a deeper breakdown of how to choose one, see our guide to the best electrolyte powders