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Singh et al, 2021), Genes common among published target sets include those related to redox biology (i.e., GCLC , SLC7A11 , TXN ) and the pentose-phosphate pathway (PPP, i.e., PGD , TALDO1 ), in addition to many NADP-dependent metabolic enzymes (i.e., AKR1C1 , AKR1B10 , and CYP4F11 )

Proc Nutr Soc 66:6981

In addition, the respective AUC values of the three-gene signature model for 1-, 3- and 5-year OS prediction in the GSE25307 dataset were 0.615, 0.688 and 0.685, respectively (Fig

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NLRP3 inflammasome, a classical indicator of pyroptosis, whose activation not only contributes to pyroptosis but also has inextricable effects on apoptosis, necroptosis, and ferroptosis (62)

This dual potential in responding to both oxidative stress and inflammation may enhance the protective capabilities of FOXO4, making it a potential factor in the cells longevity and resilience