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The accumulation of LCACs during mitochondrial FAO disorders can inhibit the activity of PPAR/PGC1, destroy the regeneration of peroxisomes, lead to increases in BCAA and ROS levels, and activate the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway

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Firsocostat and cilofexor are orally administered inhibitors that are used to target ACC in clinical drug development for the treatment of steatohepatitis associated with metabolic dysfunction (144)

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1,000mg (as sodium ascorbate) Sodium