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This hyper ECD motion was propagated to the receptor TMD, with motions within TMs 3 and 7, creating a wider TM pocket that also influences the positioning of the N-terminus of the Cagri peptide (Fig

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Instead, experimental evidence suggests that DSIP interacts indirectly with multiple receptor systems, including components of GABAergic, serotonergic, and opioid-associated pathways [1][2]

Curr Opin Obstet Gynecol 2025;37(2):97-101