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In this review article, the authors have provided a detailed overview of these strategies

The selectivity of FOXO4-DRI for senescent over non-senescent cells is mechanistically grounded: FOXO4 is expressed at low levels in most non-senescent adult cells, but is strongly upregulated in senescent cells

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First, the initial generation of DPP4 inhibitors was not completely selective for DPP4, raising the possibility that some of the actions ascribed to use of these agents in vivo may reflect off-target activity (152)

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Moreover, the expression of myostatin was downregulated in both muscle types (206)