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Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial

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The investigation specifically showed that these drugs did not increase the risk of any fractures, confirming their safety profile in clinical practice (72)

Keywords: carnitine, chronic liver disease, fatigue, frailty, hepatocellular carcinoma, metabolic flexibility, mitochondrial dysfunction, nonalcoholic fatty liver disease INTRODUCTION Carnitine is a trimethylated amino acid composed by lysine and methionine, ubiquitously present in every human cell and has an important role in energy metabolism and production of cellular energy

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