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True non-responders: uncertain outcomes If semaglutide produced absolutely no appetite suppression, no metabolic improvement, and no weight loss even at the maximum 2.4mg dose over 16 or more weeks, you may have fundamental resistance to GLP-1 receptor agonism
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Depending on the scope of the study, whole-brain c-Fos labelling can be performed using immunohistochemical (IHC) or in situ mRNA hybridization (ISH) protocols
