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Therapeutic potentials of superoxide dismutase

Nature 386 , 493495 (1997)

Its main mechanism of action is based on increasing the expression of BDNF (Brain-Derived Neurotrophic Factor) and its TrkB receptors in the hippocampus and prefrontal cortex, promoting synaptic plasticity, long-term potentiation (LTP), and memory consolidation (Dolotov et al., Neuroscience 2006)