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In addition, the expression of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the NAD+ salvage pathway, is abnormal in senescent oocytes, and the NAMPT activator P7C3 is able to promote maturation, improve spindle assembly and mitochondrial bioenergetics, and reduce mitochondrial plasma leakage in senescent oocytes, providing an opportunity to study effective NAD+ interventions [83]

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