Cell culture studies constitute a valuable tool for identifying the molecular targets modulated by dietary phenolic compounds in cancer cells and for elucidating the molecular pathways involved in the overall disease process (75)
Therefore, the precise mechanisms through which lipoxygenases contribute to ferroptosis, particularly in GPX4 inhibition contexts, require further investigation ( 3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA
MassHunter Data Analysis and MassHunter Quantitative Analysis software programs (Agilent Technologies, Barcelona, Spain) were used to collect and quantify the data, respectively
Errafii, K
FC: Formal Analysis, Validation, Writing original draft, Project administration
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