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[5], [6] DSIP has been shown to restrict stress-induced changes in mitochondrial monoamine oxidase type A (MAO-A) and serotonin levels

ROS-induced AP-1 inhibits the TGF-/Smad signaling pathway in dermal fibroblasts, which controls collagen synthesis to prevent a decrease in collagen production

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To be honest, the information on long-term human data is limited

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Clin Endocrinol (Oxf).2002;57:577-585