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The proximal tubule is the site of UA reabsorption and excretion

It is suggested that dysfunction between A production and clearance causes damaging accumulations of cellular A, coupled with hyper phosphorylation of neuronal tau protein resulting in neurofibrillary tangle formation [18-20]

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Taking into account the difference in dose administered via the two routes (a 10:1 ratio wt:wt intestinal:parenteral) a biopotency of 7% is calculated for G002