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GLP-1Rs are densely expressed in the area postrema in rats (182)

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However, unlike the natural hormone, which breaks down in minutes, agonists are chemically modified to resist degradation, allowing them to remain active in the body for hours or days to provide continuous metabolic control

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Alcohol and GLP-1 Agonists: Potential Interactions While GLP-1 agonists can be highly effective in managing diabetes and obesity, combining them with alcohol requires careful consideration