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To evaluate the real-world usefulness of the drug, the researchers calculated a clinical metric known as the number needed to treat

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However, these spikes operate on shorter timescales than the calcium transients and the longer temporal decay of intracellular calcium (on the order of tens of seconds, Fig 3) may be crucial for the negative feedback of the GPCR pathway

Patients with T2DM have twice the risk of CVD mortality compared with age-matched subjects without T2DM, approximately 10% increased risk of cancer, and poorer survival rates of cancer [4,5,6]

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