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The mice in this study were placed on a maximally tolerable restriction of both calories and protein which was accompanied by an extreme loss of up to 50% body weight

It also provides practical and case-driven opinions and recommendations on the optimal use of GLP-1RAs by discussing important patient factors and clinical considerations that will help to identify those who are most likely to benefit from this class of agents

GLP-1 (glucagon-like peptide-1) medications belong to a class of drugs designed to mimic the action of the natural hormone GLP-1

Spatial sorting enables comprehensive characterization of liver zonation

According to the national regulation on retrospective studies using anonymised data, patients informed consent was waived

2025;6(3):e245586