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Hypoglycaemia: Whilst the risk is lower than with insulin or sulphonylureas, low blood glucose can occur, particularly in individuals also taking other glucose-lowering agents

Healthcare professionals should advise patients on the early signs of NAION and to discontinue semaglutide immediately if the condition is suspected

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GIP enhances fat metabolism, improves insulin sensitivity in adipose tissue, and may protect against some of the nausea that pure GLP-1 agonists cause

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Therefore, the decision-making process must balance the need for effective diabetes management against the precautionary principle of avoiding medications with unknown safety profiles in lactation