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placebo) Significant reductions in waist circumference a proxy for visceral fat, which is the metabolically harmful kind Improvements in fasting glucose and insulin resistance markers even in people without type 2 diabetes Early cardiovascular signal : reductions in blood pressure and lipids, though this is not yet the primary endpoint of ongoing trials Phase 3 trials are ongoing

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While most are mild , practitioners should be aware of both common and rare reactions: Common : mild soreness at the injection site, flushing, or temporary nausea