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The activation of FGFR1c by intracellular phosphate results in increased expression of the GALNT3 gene which encodes the enzyme, N -acetylgalactosaminyltransferase 3

Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning

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Monitoring combines objective tests and patient reports

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ITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors