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Unfortunately, our world is far from ideal

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This correlates with the fact that if the field animals need to respond again and again to a variety of cues and filter out essential chemosensory information like predator cues, not re-using animals for experiments, even after direct handling, makes no ecological sense

In the condition of hypoxia and ischemia/reperfusion, hyperphosphorylation of COX subunit I, IV, and V (COX1, COX2, and COX5) inhibited COX activity, resulting in an increase of ROS production (Prabu et al., 2006