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Despite G6PD-d classically leading to reduced NADPH bioavailability, NADPH oxidase-dependent ROS production was also increased 28,29

Quick Answer: Wegovy does not directly cause haemorrhoids, but its gastrointestinal side effectsparticularly constipation affecting approximately 24% of usersmay indirectly increase the risk of developing or worsening haemorrhoids through straining during bowel movements

The Phase 3 TRIUMPH trials use a similar protocol

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