Older people may need a higher dosage to achieve the same effect as younger people
With heterogeneous evidence of the cardiovascular benefit, mortality, and potential risks of intensive glycemic control reported in several recent clinical trials, achieving good blood glucose control without increasing cardiovascular risk factors such as hypoglycemia and body weight gain is becoming more important [3,4,5,6,7]
The common thread across all these products is a gap between marketing claims and clinical evidence
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Accordingly, serine deprivation or SSP blockade restores the sensitivity of colorectal cancer cells to 5-FU ( 6.2.2 Targeted therapy resistance 6.2.2.1 BRAF inhibitor resistance Proteomic analysis of acquired-resistance cell lines revealed altered expression of serine biosynthetic enzymes (PHGDH, PSPH, PSAT1) in drug-resistant cells
Monitor experimental variables carefully for reproducibility