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Innovative strategies include drug repurposing

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W., Rogers, W

Protective nutrients with antioxidant properties that may help to mitigate oxidative stress, produced by phase I enzyme activity, include: Carotenes (Vitamin A) Ascorbic acid (Vitamin C) Tocopherols (Vitamin E) and selenium Copper, zinc, and manganese Coenzyme Q10, Thiols (found in garlic, onions, and cruciferous vegetables) Silymarin Bioflavonoids and polyphenols Detox Phase II: Conjugation Phase I activation results in the generation of reactive intermediates, which are often even more reactive and potentially more toxic than the parent molecule

The upregulation of IGFBP4 (encodes for a protein that binds insulin-like growth factors I and II 26 ), was shown to function as a potent tumor suppressor in hepatocellular carcinoma and delay tumor formation in prostate cancer cells 41,42

71 , 621S629S (2000)