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Stepensky D, Friedman M, Raz I, Hoffman A (2002) Pharmacokineticpharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect

Now for the games, or 'ROMs' as they're called

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That framing matters for understanding who benefits most from optimizing the protocol

Oral compound formulations are also emerging