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Additionally, ChaC1, by stimulating the GCN2/eIF2/ATF4 pathway, enhances necroptosis induced by cystine deprivation (54)

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GSH, GSSG (enzymatic assays), 15LO1, GPX4, SLC7A11, and T2 biomarkers (Western blot and RNA-Seq) were measured in asthmatic and healthy control (HC) cells and fluids, with siRNA knockdown as appropriate