In addition to traditional comorbidities, cognitive impairment, which represents an independent risk factor for HF, significantly increases the hospitalization and mortality, and decreases quality of life of patients with HF (Dodson et al., 2013
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Data availability statement The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request
Nonetheless, 7 h after single subcutaneous administration, GLP-1GIPLani induced 350 proteins in the brainstem relative to vehicle compared with only 94 proteins induced by GLP-1GIP, and this was accompanied by a marked shift in the PCA of the proteome (Fig
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This data helps distinguish GLP-1related effects from other causes and informs whether melatonin or alternative strategies are warranted