The STEP clinical trial program, which evaluated higher doses of semaglutide (2.4 mg weekly) for chronic weight management, demonstrated significantly higher rates of vomiting, with approximately 20-25% of participants reporting this adverse effect during the study period
A large multinational cohort study spanning three countries, alongside another randomized controlled trial, both concluded that GLP-1RAs usage was not associated with a significant increase in thyroid cancer risk [2, 5]
Moreover, studies in PCOS patients treated with NAC (1.8 g/day for 6 weeks) have shown a decrease in receptor tyrosine kinase c-kit protein levels in follicular fluid, while the expression of growth differentiation factor-9 in mature oocytes increases, suggesting that NAC may enhance oocyte maturation and embryo quality [60]
doi: 10.1089/ars.2023.0234 57 VandewynckelY
Clin Res Cardiol 105(10):873879
Sci Rep 14 , 28099 (2024)