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In pyramidal cells from the somatosensory cortex layer 2/3 of the same AD model, t-LTP is significantly decreased at 3.5 months old mice and abolished at 7 months old animals (Shemer et al., 2006)

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In order to validate this dopamine-depletion model, we had animals from both vehicle and AMPT groups placed in open-field chambers on three consecutive days to record their baseline locomotor activity