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Therefore, novel therapeutic development is focused on promoting or inhibiting S-nitrosation or restoring a balance between S-nitrosation and denitrosation in tumor cells, thus specifically targeting tumor progression

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In contrast, impaired tissue glucose uptake in response to insulin (a phenomenon called insulin resistance) plays a key role in the development of type 2 diabetes (55)

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10.1371/journal.pone.0120228 PLoS One 69 HosokawaY.MonzenS.YoshinoH.TerashimaS.NakanoM.ToshimaK.et al (2015)