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In addition, a decrease in androgens/AR level in males with obesity and diabetes is often accompanied by mitochondrial dysfunction, as evidenced by a study showing that male rats experienced myocardial mitochondrial ROS accumulation and enhanced apoptosis after four weeks of castration, whereas these disorders did not occur until week eight in rats of the sham group (69)

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IDPs frequently play a central role in protein interaction networks, acting as hubs that connect to many other proteins (Dunker et al., 2005

In early studies, the proximity of fluorescently labeled sites on biological macromolecules was analyzed by the ensemble FRET, which provided averaged information about the distances between labeled parts of proteins