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It works best alongside a healthy diet and regular exercise

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Retatrutide Is Not Yet Available in the UK Retatrutide remains an investigational medicine

Because GLP-1 drugs are expensive, can be difficult to access, and have significant side effects, many people have sought to increase their production of the natural hormone via nutritional modifications

Part of the paradox is thought to be explained by health

Source: West, S et al Weight regain after cessation of medication for weight management: systematic review and meta-analysis, BMJ January, 2026 Newer incretin mimetics are the GLP-1 medications semaglutide and tirzepatide