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Female ApoE / mice were used in this study because of a more prominent flavine monooxygenase 3 (FMO3) activity and a notable increase in plasma TMAO than those in male ApoE / mice according to a previous report 56,57

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The protective role of nutritional antioxidants - including glutathione precursors and direct glutathione supplementation - against impaired redox homeostasis in thyroid pathologies has been highlighted in a comprehensive review in PMC (2023), which confirmed that antioxidant interventions represent a promising adjunct strategy in the management of various thyroid conditions

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