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63 Together, these findings indicate that (i) the sensitivity of tumors to insulin and IGF-1 parallels their response to CR, and (ii) neither the activation status of PI3KAKT per se nor mutation status of individual genes predicts for the sensitivity of tumors to both growth factors and CR

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Oxidative stress, a critical component of Parkinsons pathology, was evaluated through biochemical assays of markers such as glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD)

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