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Gamma-glutamyl transpeptidase catalyses the first step in the degradation of glutathione (Figure 1)

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According to StatPearls (NCBI Bookshelf), the most common adverse effect of intramuscular vitamin B12 injections is significant pain at the injection site, which is particularly noted in thinner individuals

The addition of glutathione makes the toxic compounds more water-soluble and thus able to be excreted in urine or feces.[ref] GSTM1 enzyme: This enzyme helps the body detoxify several types of carcinogens, drugs, toxins, and oxidative stress byproducts

Biol Psychiatr 1999;46:4204