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Injection site reactions, including bruising, are documented adverse effects in semaglutide clinical trials, though bruising is not separately reported in FDA labeling

Lifestyle modifications constitute the most effective and fundamental management approach, but they often pose challenges in sustaining long-term clinical benefits

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This helps explain why many people taking GLP-1 medications report significant reductions in their desire to eat, especially high-calorie or sweet foods

Finally, tirzepatide was associated with significantly reduced occurrence of a composite kidney outcome comprising new-onset MA, 40% eGFR decline, end-stage renal disease and death due to kidney failure (HR 0.58, 95% CI 0.430.80) [49]