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Patients with diabetes are considered for cardiovascular disease secondary prevention because their risk level is similar to that reported in patients without diabetes who have already suffered a myocardial infarction

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doi:10.1371/journal.pone.0119479 41

The D-Phe stereochemistry and Nle substitution were specifically selected to resist enzymatic proteolysis, as established in the precursor work (Sawyer 1980, PMID 6777774)