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This mechanism differs fundamentally from traditional smoking-cessation medications like varenicline or bupropion, which work through different neurochemical pathways

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It also suppresses p38 MAPK signaling, another pathway involved in cellular stress responses

Michael Brandwein Aug 27, 2025 6 min read Updated: Nov 14, 2025 For more information on our content creation process, view our Editorial Policy

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Having a baseline measurement allows the prescribing team to monitor for clinically significant changes over time and adjust the protection plan accordingly