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GLP-1R signaling in the brain exerts antidepressive effects by improving cognitive processes, promoting neuroprotection and neurotransmitter release Patients suffering from depression are characterized by impaired neuronal activity and synaptic plasticity dysfunction, resulting in volumetric changes in brain regions which regulate emotions or the stress response such as the hippocampus and the prefrontal cortex

The choice depends on research protocol preferences

One would still need to know if GLP-1s make it a lot harder to save muscle in spite of strength training and prioritizing protein (certainly makes it harder to eat) -- to give thorough advice to people

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You can make your own protein shakes at home using Designs for Health's WheyCool or similar products

The biological activity can be assessed using a colorimetric bioassay consisting of the engineered cell line HEK-Blue GLP-1 expressing the GLP-1R together with a CREB-inducible SEAP reporter gene (see figure)