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Notably, the phase 3 ESSENCE trial, not included in the present algorithm because it was published after 31 January, 2025, showed that semaglutide was associated with a significant improvement in MASH and liver fibrosis 11 similar to tirzepatide

Clin Chim Acta (2016) 454:2832

[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Klotsman M, Adin CA, Anderson WH, Gilor C

For most people, consistency is key, so taking it at the same time each day is recommended

Notably, the study did not mention an increased fracture risk associated with semaglutide, despite the fact that this information is currently reported elsewhere [80]

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