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The relatively short plasma half-life of 2.7 hours (range 1.9-4.0 hours) reflects this enzymatic breakdown

GHK-Cu was first isolated from human plasma by Loren Pickart in 1973 and identified as the factor responsible for old human liver tissue behaving like young tissue in cell culture assays

Clinically, motilin receptors have become therapeutic targets for prokinetic agents, particularly motilides such as erythromycin, though long-term efficacy is limited by receptor desensitization

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The side effect is relatively new to physicians

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