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Chen J, Liu J, Wang Y et al (2017) Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPAR/AdipoR2, in vivo and in vitro

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Adicionalmente, caso o sintoma ocorra durante o aumento progressivo da dose, o estudo recomenda estender o uso da menor dose por mais algumas semanas e evitar o aumento da dose na vigncia de sintomas gastrointestinais

So far, trials have not demonstrated gross impairment of growth or bone mineral density, and some data suggest possible bone-protective effects, but pediatric data are limited (37)

For example, caspase-8 cleaves GSDMC, GSDMD, and GSDME (Orning et al., 2018

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