AOD-9604 does not cause receptor desensitization or hormonal suppression, so the break is precautionary rather than biologically required
Oral Administration Subcutaneous (SubQ) Injection Injected just under the skin, typically near the site of injury Best for targeted healing of tendons, ligaments, joints, and muscles Fast absorption and high local bioavailability Injection sites : Shoulder issues : Lateral deltoid, upper bicep Knee or patella tendonitis : Around the lower thigh or above kneecap Ankle or Achilles pain : Outer calf or above heel Elbow or wrist pain : Forearm or triceps area How to inject SubQ : Use an insulin syringe (2931G, inch) Pinch skin, insert needle at a 4590 angle Inject slowly, rotate injection sites daily Inject 12 inches away from direct injury to avoid tissue trauma Intramuscular (IM) Injection Less common, but can be used when injecting deeper tissues or larger muscles Administer into lateral deltoid, glutes, or vastus lateralis May increase discomfort
This is not a numbing effect, but rather one that restores emotional balance
Appl Clin Genet
Mol Cell Endocrinol 2015;417:1-9
Meng G, Chai K, Li X, Zhu Y, Huang W (2016) Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway