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While the neuroprotective effect in preclinical studies is clear, clinical findings have so far failed to demonstrate an arresting effect on cognitive

2G), was used to measure the impact of acute stimulation of glucose transport in freshly harvested rat quadriceps muscle

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In December 2023, Pfizer discontinued the twice-daily formulation due to tolerability issues, and in June 2024, the once-daily version failed to meet efficacy and tolerability targets