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Side effects such as nausea or digestive discomfort can feel more noticeable during perimenopause and menopause because sleep disruption, hormonal fluctuations, and digestive changes can influence how the body tolerates dose increases

For people living with diabetes, it helps lower blood sugar levels by stimulating insulin release only when glucose is present, reducing the risk of hypoglycemia

This adaptation typically emerges after 36 months of consistent semaglutide use, causing hunger cues to gradually return and appetite suppression to diminish

Diet and timing strategies help

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Dose escalation beyond 2mL weekly is uncommon and not supported by additional metabolic benefit