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SGLT-2, sodium-glucose cotransporter-2

Tirzepatide targets both GLP-1 and GIP receptors, similar to Retatrutide

Summary: Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) showing promising early weight-loss and metabolic data in Phase 2 trials, but it is not yet approved in the UK and carries notable side effects and safety uncertainties

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While semaglutide targets only GLP-1 receptors and tirzepatide targets GIP and GLP-1, Retatrutide adds glucagon receptor activity unlocking an additional fat-burning and energy-expenditure pathway that the others simply cannot match

"Top-line results" means the key findings: did people lose significantly more weight than placebo, and was the drug safe enough