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Furthermore, numerous NCI-60 cell lines (60 human cancer cell lines used by the National Cancer Institute) were purchased from the National Cancer Institutes Developmental Therapeutics Program (NCI), including Hop62 (a human lung adenocarcinoma epithelial cell line), Hop92 (a human lung non-small lung cancer cell line), H1650 (a human lung adenocarcinoma epithelial cell line), H23 (a human lung adenocarcinoma epithelial cell line), and H460 (a human lung non-small lung cancer cell line)

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& Rosenfeld, R

These reactions are often blamed on detox, but they may indicate that folate treatment does not match the patients underlying methylation pattern

The reasons for a generally low toxicity toward mammalian cells by AF are not known but could involve low uptake or efficient metabolic defense systems