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Cells generate localized ROS near the nuclear envelope (NOX isoforms), the outer mitochondrial membrane (MAO facing the cytosol) and cytosolic dehydrogenase complexes adjoining the nucleus (Kaludercic et al

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A study involving mice also found that the release of free copper ions induced neointimal thickening and contributed to the development of atherosclerotic lesions in damaged rat carotid arteries (62)

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White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation

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