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23 These symptoms can be severe in some patients, resulting in a pause of dose escalation, and if intolerable GI symptoms continue, a dose adjustment to the previous lower dose or a switch to an alternative GLP-1 RA should be considered

JAMA Network Open

Patients often present with resistance to the initiation of an injectable agent

The use of functional MRI to study appetite control in the CNS

Heffron and his colleagues also conducted a subgroup analysis, collecting trials that compared GLP-1 agonists with DPP-4 inhibitors (an older class of diabetes medications), both of which raise blood levels of GLP-1

When switching, your doctor will start you on a low dose of semaglutide GLP-1